Human immunodeficiency virus is a virus that is able to cause a condition that is known as acquired immunodeficiency syndrome which in humans, causes our immune system to fail which then allows other pathogens to be able to infect the body which otherwise, it wouldn’t have been able to do.
HIV is a member of the genus Lentivirus which is a part of
the family known as Retroviridae. All lentiviruses are transmitted as a single-strained enveloped RNA virus which when enters the cell, is converted to a double stranded DNA by an encoded reverse transcriptase that was within the virus particle.
Once this is done, it is then able to be integrated into the host cellular co-factors so that the genome is able to be transcribed. Once this happens, there is only two outcomes.
- The virus becomes latent which then allows the cell to be able to function normally (in this case, it still does the next part but often delayed).
- The virus becomes active which then causes the cell to replication along with a large number of the virus.
Once this has happened, the new viruses are free to be able to infect any other cell that it is able to. The video below in this article shows what I have just written in slightly more detail but it is much more easy to follow.
There is two known strains of the virus which is HIV-1 & HIV –2. The first one being HIV-1 is the one that was first discovered and it is the most easy transmitted out of the two and it is the cause of most HIV infections globally. HIV-2 is less transmittable then HIV-1 and it is mostly confined to West Africa.
At this current time, HIV isn’t curable. One of the major reason for why this is the case is that the virus goes to attack the immune system which stops our bodies from being able to fight the HIV. However, there is treatment and as you will read in the rest of this article, a possible solution to HIV.
If you are infected with HIV, chances are that you will not be affected by it however more then likely you will be needing to take what is known as anti-viral drugs to be able to live longer then a year or so if you wasn’t taking them. The different anti-viral drugs that are taken is listed in the table below (Data taken from AVERT)
| Antiretroviral drug class | Abbreviations | First approved to treat HIV | How they attack HIV |
| Nucleoside/Nucleotide Reverse Transcriptase Inhibitors | NRTIs, nucleoside analogues, nukes | 1987 | NRTIs interfere with the action of an HIV protein called reverse transcriptase, which the virus needs to make new copies of itself. |
| Non-Nucleoside Reverse Transcriptase Inhibitors | NNRTIs, non-nucleosides, non-nukes | 1997 | NNRTIs also stop HIV from replicating within cells by inhibiting the reverse transcriptase protein. |
| Protease Inhibitors | PIs
| 1995 | PIs inhibit protease, which is another protein involved in the HIV replication process. |
| Fusion or Entry Inhibitors | | 2003 | Fusion or entry inhibitors prevent HIV from binding to or entering human immune cells. |
| Integrase Inhibitors | | 2007 | Integrase inhibitors interfere with the integrase enzyme, which HIV needs to insert its genetic material into human cells. |
The anti-viral drugs works by slowing down (or hopefully stopping) certain stages of what happens when you are infected by HIV. However, there is one problem still that has been researched by many HIV researchers for many years.
How do you deal with a virus which attacks the immune system that is trying to fight it off
Well, it seems they might be a solution which goes against all the typical methods of fighting off viruses – Bypass the immune system all together.
As you know, the immune system is the system in your body that fights of infections however HIV is able to defeat it. But some researchers has been able to protect nine macaques against the monkey form of HIV (simian-immunodefiency virus). Their idea is rather then making the immune system be prepared to be able to fight the virus, they turned the monkey muscle cells into “factories” which then creates many antibodies that is able to kill the SIV.
This was done by Philip Johnson of the Children’s Hospital of Philadelphia in Pennsylvania and his colleagues. They are hoping to be able to have this in clinical trials within 2-3 years given the strong proof of principle.
HIV Replication Animation
Incase you wanted to see how HIV is able to infect the human immune system or that the article I have written doesn’t explain or maybe you just like seeing videos rather then text.
Regardless of the reason, the video below is a very good video in showing how the virus is able to infect the cells. Bear in mind this is an animation, not seeing the actual virus infecting cells as this is next to impossible to record at this time.
HIV Replication 3D Medical Animation
References
Andy Coghlan. (2009). Muscle "immunity" weigh in against monkey HIV.. NewScientist. 2709 (1), p12.
Dr. A. Rufus. (2007). HIV Replication 3D Medical Animation. Available: http://www.youtube.com/watch?v=RO8MP3wMvqg. Last accessed 27 May 2009.
International Committee on Taxonomy of Viruses. (2006).00.061.1.06. Lentivirus. Available: http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/index.htm. Last accessed 27 May 2009.